Gender and genotype modulation of the association between lipid levels and depressive symptomatology in community-dwelling elderly (the ESPRIT study).
Identifieur interne : 001735 ( Main/Exploration ); précédent : 001734; suivant : 001736Gender and genotype modulation of the association between lipid levels and depressive symptomatology in community-dwelling elderly (the ESPRIT study).
Auteurs : Marie-Laure Ancelin [France] ; Isabelle Carrière [France] ; Jean-Philippe Boulenger [France] ; Alain Malafosse [France] ; Robert Stewart [France] ; Jean-Paul Cristol [France] ; Karen Ritchie [France] ; Isabelle Chaudieu [France] ; Anne-Marie Dupuy [France]Source :
- Biological Psychiatry [ 0006-3223 ] ; 2010-07-15.
English descriptors
- mix :
Abstract
BACKGROUND: Lipids appear to mediate depressive vulnerability in the elderly; however, sex differences and genetic vulnerability have not been taken into account in previous prospective studies. METHODS: Depression was assessed in a population of 1040 women and 752 men aged 65 years and older at baseline and after 7-year follow-up. Clinical level of depression (DEP) was defined as having either a score of 16 or higher on the Centre for Epidemiology Studies Depression scale or a diagnosis of current major depression on the Mini-International Neuropsychiatric Interview. Lipid levels, apolipoprotein E, and serotonin transporter linked promoter region (5-serotonin transporter gene linked promoter region) genotypes were evaluated at baseline. RESULTS: Multivariate analyses adjusted by sociodemographic and behavioral variables, measures of physical health including ischemic pathologies, and genetic vulnerability indicated gender-specific associations between dyslipidemia and DEP, independent of the use of lipid-lowering agents or apolipoprotein E status. Men with low low-density lipoprotein cholesterol levels had twice the risk of prevalent and incident DEP, whereas in women low high-density lipoprotein cholesterol levels were found to be significantly associated with increased prevalent DEP (odds ratio = 1.5) only. A significant interaction was observed between low low-density lipoprotein-cholesterol and 5-serotonin transporter gene linked promoter region genotype, men with s/s or s/l genotype being at increased risk of DEP (odds ratio = 6.0 and 2.7, respectively). No significant gene-environment interaction was observed for women. CONCLUSIONS: DEP is associated with higher atherogenic risk in women (low high-density lipoprotein cholesterol), whereas the reverse is observed in men (low low-density lipoprotein cholesterol). Late-life depression may have a complex gender-specific etiology involving genetic vulnerability in men.
Url:
DOI: 10.1016/j.biopsych.2010.04.011
Affiliations:
- France
- Languedoc-Roussillon, Occitanie (région administrative)
- Montpellier
- PRES Sud de France, Université Montpellier 1
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Le document en format XML
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<orgName type="acronym">UM</orgName>
<desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
<country key="FR"></country>
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<ref type="url">http://www.umontpellier.fr/</ref>
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<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
<orgName type="university">Université Montpellier 1</orgName>
<orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName>
</affiliation>
</author>
<author><name sortKey="Chaudieu, Isabelle" sort="Chaudieu, Isabelle" uniqKey="Chaudieu I" first="Isabelle" last="Chaudieu">Isabelle Chaudieu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139836" status="VALID"> <idno type="RNSR">201120699F</idno>
<orgName>Neuropsychiatrie : recherche épidémiologique et clinique</orgName>
<desc> <address> <addrLine>Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier</addrLine>
<country key="FR"></country>
</address>
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<tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName>
<orgName type="acronym">UM1</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine>
<country key="FR"></country>
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<ref type="url">http://www.univ-montp1.fr/</ref>
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<tutelle name="U1061" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
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<ref type="url">http://www.inserm.fr</ref>
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<tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno>
<orgName>Université de Montpellier</orgName>
<orgName type="acronym">UM</orgName>
<desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.umontpellier.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
<orgName type="university">Université Montpellier 1</orgName>
<orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName>
</affiliation>
</author>
<author><name sortKey="Dupuy, Anne Marie" sort="Dupuy, Anne Marie" uniqKey="Dupuy A" first="Anne-Marie" last="Dupuy">Anne-Marie Dupuy</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139836" status="VALID"> <idno type="RNSR">201120699F</idno>
<orgName>Neuropsychiatrie : recherche épidémiologique et clinique</orgName>
<desc> <address> <addrLine>Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier</addrLine>
<country key="FR"></country>
</address>
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<tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName>
<orgName type="acronym">UM1</orgName>
<date type="end">2014-12-31</date>
<desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-montp1.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U1061" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
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<orgName>Université de Montpellier</orgName>
<orgName type="acronym">UM</orgName>
<desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.umontpellier.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Montpellier</settlement>
<region type="region" nuts="2">Occitanie (région administrative)</region>
<region type="old region" nuts="2">Languedoc-Roussillon</region>
</placeName>
<orgName type="university">Université Montpellier 1</orgName>
<orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.biopsych.2010.04.011</idno>
<series><title level="j">Biological Psychiatry</title>
<idno type="ISSN">0006-3223</idno>
<imprint><date type="datePub">2010-07-15</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Depression</term>
<term>elderly</term>
<term>gender differences</term>
<term>gene-environment interaction</term>
<term>lipid</term>
<term>serotonin transporter (5-HTTLPR)</term>
<term>serotonin transporter (5-HTTLPR).</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>BACKGROUND: Lipids appear to mediate depressive vulnerability in the elderly; however, sex differences and genetic vulnerability have not been taken into account in previous prospective studies. METHODS: Depression was assessed in a population of 1040 women and 752 men aged 65 years and older at baseline and after 7-year follow-up. Clinical level of depression (DEP) was defined as having either a score of 16 or higher on the Centre for Epidemiology Studies Depression scale or a diagnosis of current major depression on the Mini-International Neuropsychiatric Interview. Lipid levels, apolipoprotein E, and serotonin transporter linked promoter region (5-serotonin transporter gene linked promoter region) genotypes were evaluated at baseline. RESULTS: Multivariate analyses adjusted by sociodemographic and behavioral variables, measures of physical health including ischemic pathologies, and genetic vulnerability indicated gender-specific associations between dyslipidemia and DEP, independent of the use of lipid-lowering agents or apolipoprotein E status. Men with low low-density lipoprotein cholesterol levels had twice the risk of prevalent and incident DEP, whereas in women low high-density lipoprotein cholesterol levels were found to be significantly associated with increased prevalent DEP (odds ratio = 1.5) only. A significant interaction was observed between low low-density lipoprotein-cholesterol and 5-serotonin transporter gene linked promoter region genotype, men with s/s or s/l genotype being at increased risk of DEP (odds ratio = 6.0 and 2.7, respectively). No significant gene-environment interaction was observed for women. CONCLUSIONS: DEP is associated with higher atherogenic risk in women (low high-density lipoprotein cholesterol), whereas the reverse is observed in men (low low-density lipoprotein cholesterol). Late-life depression may have a complex gender-specific etiology involving genetic vulnerability in men.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Languedoc-Roussillon</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement><li>Montpellier</li>
</settlement>
<orgName><li>PRES Sud de France</li>
<li>Université Montpellier 1</li>
</orgName>
</list>
<tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name>
</region>
<name sortKey="Boulenger, Jean Philippe" sort="Boulenger, Jean Philippe" uniqKey="Boulenger J" first="Jean-Philippe" last="Boulenger">Jean-Philippe Boulenger</name>
<name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name>
<name sortKey="Chaudieu, Isabelle" sort="Chaudieu, Isabelle" uniqKey="Chaudieu I" first="Isabelle" last="Chaudieu">Isabelle Chaudieu</name>
<name sortKey="Cristol, Jean Paul" sort="Cristol, Jean Paul" uniqKey="Cristol J" first="Jean-Paul" last="Cristol">Jean-Paul Cristol</name>
<name sortKey="Dupuy, Anne Marie" sort="Dupuy, Anne Marie" uniqKey="Dupuy A" first="Anne-Marie" last="Dupuy">Anne-Marie Dupuy</name>
<name sortKey="Malafosse, Alain" sort="Malafosse, Alain" uniqKey="Malafosse A" first="Alain" last="Malafosse">Alain Malafosse</name>
<name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name>
<name sortKey="Stewart, Robert" sort="Stewart, Robert" uniqKey="Stewart R" first="Robert" last="Stewart">Robert Stewart</name>
</country>
</tree>
</affiliations>
</record>
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